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This relationship provides thephysiologic basis for many goal-directed thera-pies that are routinely implemented in the ICU(Shoemaker et al.

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There is high uptake in 2 or 4 and 24 hours, but rapid fall after 48 hours. ‘Dementia effects the dismantling of theself until there is nothing left’ (Davis 2004: 374). ‘Why doesn’t everyone justleave me?’ he said to me during one of my visits in the spring.

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